Drug interactions
Doxepin + Verapamil
Severity: Moderate
Doxepin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise doxepin concentrations, increasing sedation, anticholinergic effects and orthostatic hypotension. Additive effects on cardiac conduction may also occur.
What this interaction means in plain words
Doxepin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP-mediated metabolism of doxepin (CYP3A4 and others).
What to do
Monitor sedation, blood pressure and ECG, and lower the doxepin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Verapamil?
MediHelp rates the interaction as moderate. Doxepin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise doxepin concentrations, increasing sedation, anticholinergic effects and orthostatic hypotension. Additive effects on cardiac conduction may also occur.
How serious is the interaction between Doxepin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and ECG, and lower the doxepin dose if adverse effects appear.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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