Drug interactions
Doxorubicin + Nevirapine
Severity: Minor
Doxorubicin and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine could speed doxorubicin clearance and alter its exposure, but the clinical importance is uncertain because doxorubicin is cleared mainly by other routes such as carbonyl reduction and biliary excretion. The effect on antitumor activity or toxicity is not well characterized.
What this interaction means in plain words
Doxorubicin and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which plays only a minor role in doxorubicin metabolism, so any effect is predicted rather than established.
What to do
No empirical dose change is needed; monitor tumor response and blood counts as usual during chemotherapy. Be aware of possible reduced effect if response is poorer than expected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Nevirapine?
MediHelp rates the interaction as minor. Doxorubicin and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine could speed doxorubicin clearance and alter its exposure, but the clinical importance is uncertain because doxorubicin is cleared mainly by other routes such as carbonyl reduction and biliary excretion. The effect on antitumor activity or toxicity is not well characterized.
How serious is the interaction between Doxorubicin and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor tumor response and blood counts as usual during chemotherapy. Be aware of possible reduced effect if response is poorer than expected.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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