Drug interactions
Doxorubicin + Ranolazine
Severity: Moderate
Doxorubicin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, which helps pump doxorubicin out of cells and eliminate it. Exposure to doxorubicin may rise, with a possible increase in myelosuppression and cardiotoxicity. The clinical significance has not been well characterized.
What this interaction means in plain words
Doxorubicin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits P-glycoprotein efflux, which may reduce doxorubicin clearance and raise tissue exposure.
What to do
Monitor blood counts and cardiac function more closely during concurrent therapy. Consider an alternative antianginal if doxorubicin toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Ranolazine?
MediHelp rates the interaction as moderate. Doxorubicin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein, which helps pump doxorubicin out of cells and eliminate it. Exposure to doxorubicin may rise, with a possible increase in myelosuppression and cardiotoxicity. The clinical significance has not been well characterized.
How serious is the interaction between Doxorubicin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function more closely during concurrent therapy. Consider an alternative antianginal if doxorubicin toxicity develops.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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