Drug interactions
Doxorubicin + Rucaparib
Severity: Minor
Doxorubicin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4 substrates. CYP3A4 is a minor route for doxorubicin, so the effect is probably small, but additive myelosuppression is also possible.
What this interaction means in plain words
Doxorubicin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, potentially reducing doxorubicin metabolism.
What to do
Monitor blood counts and cardiac status. Adjust the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Doxorubicin with Rucaparib?
MediHelp rates the interaction as minor. Doxorubicin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4 substrates. CYP3A4 is a minor route for doxorubicin, so the effect is probably small, but additive myelosuppression is also possible.
How serious is the interaction between Doxorubicin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status. Adjust the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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