Drug interactions
Doxorubicin + Stiripentol
Severity: Moderate
Doxorubicin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein, BCRP and CYP3A4, and can also induce CYP3A4. Doxorubicin exposure may therefore rise, with more myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-gp, BCRP and CYP3A4, potentially reducing doxorubicin clearance.
What to do
Monitor blood counts and cardiac function. Reduce the doxorubicin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Stiripentol
Frequently asked questions
Can I take Doxorubicin with Stiripentol?
MediHelp rates the interaction as moderate. Doxorubicin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits P-glycoprotein, BCRP and CYP3A4, and can also induce CYP3A4. Doxorubicin exposure may therefore rise, with more myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Reduce the doxorubicin dose if adverse effects occur.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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