Drug interactions
Doxorubicin + Vadadustat
Severity: Moderate
Doxorubicin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase exposure to BCRP substrates such as doxorubicin. This could heighten myelosuppression and cardiotoxicity, although the clinical data are lacking.
What this interaction means in plain words
Doxorubicin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP, reducing efflux of doxorubicin.
What to do
Monitor blood counts and cardiac function, and reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Doxorubicin with Vadadustat?
MediHelp rates the interaction as moderate. Doxorubicin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and may increase exposure to BCRP substrates such as doxorubicin. This could heighten myelosuppression and cardiotoxicity, although the clinical data are lacking.
How serious is the interaction between Doxorubicin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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