Drug interactions
Doxorubicin + Vinflunine
Severity: Moderate
Doxorubicin and Vinflunine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The interaction was characterized with the pegylated liposomal formulation, and its relevance to conventional doxorubicin is unclear. Both drugs are myelosuppressive, so additive hematologic toxicity is possible.
What this interaction means in plain words
Doxorubicin and Vinflunine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Vinflunine belongs to Oncology.
Why it happens
Additive myelosuppression; a pharmacokinetic interaction with conventional doxorubicin is not established.
What to do
Monitor complete blood counts and cardiac function, and adjust doses according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinflunine
- Itraconazole + Vinflunine Major
- Ketoconazole + Vinflunine Major
- Rifampicin + Vinflunine Major
- Ritonavir + Vinflunine Major
- Liposomal doxorubicin + Vinflunine Moderate
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Vinflunine?
MediHelp rates the interaction as moderate. Doxorubicin and Vinflunine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The interaction was characterized with the pegylated liposomal formulation, and its relevance to conventional doxorubicin is unclear. Both drugs are myelosuppressive, so additive hematologic toxicity is possible.
How serious is the interaction between Doxorubicin and Vinflunine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and cardiac function, and adjust doses according to toxicity.
What other medicines interact with Vinflunine?
MediHelp also lists interactions of Vinflunine with, for example, Itraconazole, Ketoconazole, Rifampicin. The full list is on the Vinflunine page.
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