Drug interactions
Ritonavir + Vinflunine
Severity: Major
Ritonavir and Vinflunine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and can raise vinflunine exposure, increasing risks of neutropenia, constipation and other toxicities. The labeling advises avoiding potent CYP3A4 inhibitors.
What this interaction means in plain words
Ritonavir and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ritonavir belongs to Anti Virals; Vinflunine belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated vinflunine metabolism raises plasma concentrations.
What to do
Avoid the combination where possible. If unavoidable, monitor blood counts and bowel function closely and consider a vinflunine dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinflunine
- Itraconazole + Vinflunine Major
- Ketoconazole + Vinflunine Major
- Rifampicin + Vinflunine Major
- Doxorubicin + Vinflunine Moderate
- Liposomal doxorubicin + Vinflunine Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Vinflunine?
MediHelp rates the interaction as major. Ritonavir and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and can raise vinflunine exposure, increasing risks of neutropenia, constipation and other toxicities. The labeling advises avoiding potent CYP3A4 inhibitors.
How serious is the interaction between Ritonavir and Vinflunine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor blood counts and bowel function closely and consider a vinflunine dose reduction.
What other medicines interact with Vinflunine?
MediHelp also lists interactions of Vinflunine with, for example, Itraconazole, Ketoconazole, Rifampicin. The full list is on the Vinflunine page.
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