Drug interactions
Itraconazole + Vinflunine
Severity: Major
Itraconazole and Vinflunine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and may increase vinflunine exposure and toxicity such as neutropenia and constipation. Labeling recommends avoiding potent CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Vinflunine belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated vinflunine metabolism raises plasma concentrations.
What to do
Avoid the combination where possible, choosing an antifungal with less CYP3A4 inhibition. If unavoidable, monitor blood counts and bowel function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinflunine
- Ketoconazole + Vinflunine Major
- Rifampicin + Vinflunine Major
- Ritonavir + Vinflunine Major
- Doxorubicin + Vinflunine Moderate
- Liposomal doxorubicin + Vinflunine Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Vinflunine?
MediHelp rates the interaction as major. Itraconazole and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole strongly inhibits CYP3A4 and may increase vinflunine exposure and toxicity such as neutropenia and constipation. Labeling recommends avoiding potent CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Vinflunine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, choosing an antifungal with less CYP3A4 inhibition. If unavoidable, monitor blood counts and bowel function.
What other medicines interact with Vinflunine?
MediHelp also lists interactions of Vinflunine with, for example, Ketoconazole, Rifampicin, Ritonavir. The full list is on the Vinflunine page.
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