Drug interactions
Liposomal doxorubicin + Vinflunine
Severity: Moderate
Liposomal doxorubicin and Vinflunine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration with pegylated liposomal doxorubicin has been associated with higher vinflunine exposure and markedly lower doxorubicin exposure. This may increase vinflunine toxicity such as neutropenia and constipation while reducing doxorubicin efficacy.
What this interaction means in plain words
Liposomal doxorubicin and Vinflunine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Vinflunine belongs to Oncology.
Why it happens
The mechanism is not well established; altered distribution or clearance has been observed.
What to do
Monitor blood counts and bowel function closely and assess treatment response; adjust doses per toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinflunine
- Itraconazole + Vinflunine Major
- Ketoconazole + Vinflunine Major
- Rifampicin + Vinflunine Major
- Ritonavir + Vinflunine Major
- Doxorubicin + Vinflunine Moderate
Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Liposomal doxorubicin with Vinflunine?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Vinflunine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration with pegylated liposomal doxorubicin has been associated with higher vinflunine exposure and markedly lower doxorubicin exposure. This may increase vinflunine toxicity such as neutropenia and constipation while reducing doxorubicin efficacy.
How serious is the interaction between Liposomal doxorubicin and Vinflunine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and bowel function closely and assess treatment response; adjust doses per toxicity.
What other medicines interact with Vinflunine?
MediHelp also lists interactions of Vinflunine with, for example, Itraconazole, Ketoconazole, Rifampicin. The full list is on the Vinflunine page.
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