Drug interactions
Rifampicin + Vinflunine
Severity: Major
Rifampicin and Vinflunine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin strongly induces CYP3A4 and may lower vinflunine concentrations, potentially reducing antitumor efficacy.
What this interaction means in plain words
Rifampicin and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Vinflunine belongs to Oncology.
Why it happens
Induction of CYP3A4 increases vinflunine metabolic clearance.
What to do
Avoid the combination and use an alternative antimycobacterial where possible. If unavoidable, monitor for loss of therapeutic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinflunine
- Itraconazole + Vinflunine Major
- Ketoconazole + Vinflunine Major
- Ritonavir + Vinflunine Major
- Doxorubicin + Vinflunine Moderate
- Liposomal doxorubicin + Vinflunine Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Vinflunine?
MediHelp rates the interaction as major. Rifampicin and Vinflunine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin strongly induces CYP3A4 and may lower vinflunine concentrations, potentially reducing antitumor efficacy.
How serious is the interaction between Rifampicin and Vinflunine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimycobacterial where possible. If unavoidable, monitor for loss of therapeutic response.
What other medicines interact with Vinflunine?
MediHelp also lists interactions of Vinflunine with, for example, Itraconazole, Ketoconazole, Ritonavir. The full list is on the Vinflunine page.
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