Drug interactions
Doxorubicin liposomal + Fluconazole
Severity: Minor
Doxorubicin liposomal and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a CYP3A4 and P-glycoprotein substrate, so inhibitors could raise exposure. With liposomal formulations, the effect of such inhibition is uncertain and likely smaller.
What this interaction means in plain words
Doxorubicin liposomal and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by fluconazole reducing doxorubicin clearance; liposomal encapsulation limits relevance.
What to do
No routine adjustment is needed. Monitor for myelosuppression, mucositis and cardiac toxicity as per standard care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Fluconazole?
MediHelp rates the interaction as minor. Doxorubicin liposomal and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a CYP3A4 and P-glycoprotein substrate, so inhibitors could raise exposure. With liposomal formulations, the effect of such inhibition is uncertain and likely smaller.
How serious is the interaction between Doxorubicin liposomal and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for myelosuppression, mucositis and cardiac toxicity as per standard care.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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