Drug interactions
Doxycycline + Lurbinectedin
Severity: Minor
Doxycycline and Lurbinectedin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is mainly cleared by CYP3A4, and strong inhibitors raise its exposure and myelosuppression risk. Doxycycline is not a clinically important CYP3A4 inhibitor, so a significant effect is unlikely.
What this interaction means in plain words
Doxycycline and Lurbinectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Lurbinectedin belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition, not established for doxycycline.
What to do
No empiric dose change is needed; monitor blood counts and liver tests per lurbinectedin routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Doxycycline with Lurbinectedin?
MediHelp rates the interaction as minor. Doxycycline and Lurbinectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurbinectedin is mainly cleared by CYP3A4, and strong inhibitors raise its exposure and myelosuppression risk. Doxycycline is not a clinically important CYP3A4 inhibitor, so a significant effect is unlikely.
How serious is the interaction between Doxycycline and Lurbinectedin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor blood counts and liver tests per lurbinectedin routine.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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