Drug interactions
Doxycycline + Methoxsalen
Severity: Moderate
Doxycycline and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both doxycycline and methoxsalen cause photosensitivity. Together they can increase the risk and severity of phototoxic reactions such as severe sunburn and skin eruptions, especially during PUVA therapy.
What this interaction means in plain words
Doxycycline and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic photosensitizing effects.
What to do
Advise strict sun avoidance and photoprotection, and adjust UV dosing if phototoxicity appears. Consider an alternative antibiotic during PUVA treatment if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Doxycycline with Methoxsalen?
MediHelp rates the interaction as moderate. Doxycycline and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both doxycycline and methoxsalen cause photosensitivity. Together they can increase the risk and severity of phototoxic reactions such as severe sunburn and skin eruptions, especially during PUVA therapy.
How serious is the interaction between Doxycycline and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun avoidance and photoprotection, and adjust UV dosing if phototoxicity appears. Consider an alternative antibiotic during PUVA treatment if feasible.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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