Drug interactions
Doxycycline + Naldemedine
Severity: Minor
Doxycycline and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is partly metabolized by CYP3A4, and its exposure rises with CYP3A4 inhibitors. Doxycycline is not a clinically meaningful CYP3A4 inhibitor, so a relevant increase in naldemedine levels is unlikely.
What this interaction means in plain words
Doxycycline and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
The proposed CYP3A4 inhibition by doxycycline is not supported by clinical evidence.
What to do
No dose adjustment is needed. Be aware of opioid withdrawal-type GI symptoms such as abdominal pain or diarrhea as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Doxycycline with Naldemedine?
MediHelp rates the interaction as minor. Doxycycline and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is partly metabolized by CYP3A4, and its exposure rises with CYP3A4 inhibitors. Doxycycline is not a clinically meaningful CYP3A4 inhibitor, so a relevant increase in naldemedine levels is unlikely.
How serious is the interaction between Doxycycline and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of opioid withdrawal-type GI symptoms such as abdominal pain or diarrhea as usual.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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