Drug interactions
Doxycycline + Neratinib
Severity: Minor
Doxycycline and Neratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib is mainly metabolized by CYP3A4, and strong or moderate inhibitors can increase its exposure and diarrhea risk. Doxycycline has not been shown to be a clinically relevant CYP3A4 inhibitor, so any effect is likely small.
What this interaction means in plain words
Doxycycline and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Neratinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline, not well established.
What to do
Continue standard neratinib dosing with antidiarrheal prophylaxis and monitor for severe diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Doxycycline with Neratinib?
MediHelp rates the interaction as minor. Doxycycline and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Neratinib is mainly metabolized by CYP3A4, and strong or moderate inhibitors can increase its exposure and diarrhea risk. Doxycycline has not been shown to be a clinically relevant CYP3A4 inhibitor, so any effect is likely small.
How serious is the interaction between Doxycycline and Neratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue standard neratinib dosing with antidiarrheal prophylaxis and monitor for severe diarrhea.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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