Drug interactions
Doxycycline + Pexidartinib
Severity: Minor
Doxycycline and Pexidartinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 substrate and can cause serious liver injury, so higher exposure is a concern. Doxycycline is not an established CYP3A4 inhibitor, so a meaningful increase is unlikely.
What this interaction means in plain words
Doxycycline and Pexidartinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline.
What to do
No empiric dose change; continue the liver test monitoring required for pexidartinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Doxycycline with Pexidartinib?
MediHelp rates the interaction as minor. Doxycycline and Pexidartinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pexidartinib is a CYP3A4 substrate and can cause serious liver injury, so higher exposure is a concern. Doxycycline is not an established CYP3A4 inhibitor, so a meaningful increase is unlikely.
How serious is the interaction between Doxycycline and Pexidartinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; continue the liver test monitoring required for pexidartinib.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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