Drug interactions
Doxycycline + Voclosporin
Severity: Minor
Doxycycline and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and increased exposure raises the risk of nephrotoxicity, hypertension and other calcineurin inhibitor toxicities. Doxycycline is not an established CYP3A4 inhibitor, so the interaction is mainly theoretical.
What this interaction means in plain words
Doxycycline and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline could reduce voclosporin clearance.
What to do
Monitor eGFR, blood pressure and potassium when doxycycline is started or stopped; adjust voclosporin only if toxicity or renal decline appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Doxycycline with Voclosporin?
MediHelp rates the interaction as minor. Doxycycline and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is a CYP3A4 substrate with a narrow therapeutic window, and increased exposure raises the risk of nephrotoxicity, hypertension and other calcineurin inhibitor toxicities. Doxycycline is not an established CYP3A4 inhibitor, so the interaction is mainly theoretical.
How serious is the interaction between Doxycycline and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, blood pressure and potassium when doxycycline is started or stopped; adjust voclosporin only if toxicity or renal decline appears.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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