Drug interactions
Doxylamine + Etomidate
Severity: Moderate
Doxylamine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and doxylamine can add to its sedative and hypnotic effect. This may deepen or prolong sedation and delay recovery. It matters mainly in perioperative settings.
What this interaction means in plain words
Doxylamine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and H1 antihistamine sedation.
What to do
Tell the anesthesia team about recent doxylamine use and titrate etomidate to effect. Monitor airway, ventilation and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Doxylamine with Etomidate?
MediHelp rates the interaction as moderate. Doxylamine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and doxylamine can add to its sedative and hypnotic effect. This may deepen or prolong sedation and delay recovery. It matters mainly in perioperative settings.
How serious is the interaction between Doxylamine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent doxylamine use and titrate etomidate to effect. Monitor airway, ventilation and recovery.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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