Drug interactions
Doxylamine + Fluphenazine
Severity: Moderate
Doxylamine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating, anticholinergic antihistamine. With fluphenazine it increases drowsiness and anticholinergic effects and may impair next-day alertness.
What this interaction means in plain words
Doxylamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Counsel patients to avoid driving and alcohol, and monitor older adults for confusion, falls and urinary retention. Consider non-sedating options for sleep or allergy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Fluphenazine?
MediHelp rates the interaction as moderate. Doxylamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating, anticholinergic antihistamine. With fluphenazine it increases drowsiness and anticholinergic effects and may impair next-day alertness.
How serious is the interaction between Doxylamine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, and monitor older adults for confusion, falls and urinary retention. Consider non-sedating options for sleep or allergy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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