Drug interactions
Doxylamine + Iloperidone
Severity: Moderate
Doxylamine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that causes sedation, orthostatic hypotension and QT prolongation. Doxylamine adds sedative and anticholinergic effects, which can increase drowsiness and dizziness.
What this interaction means in plain words
Doxylamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects from H1 and receptor blockade.
What to do
Monitor for oversedation, orthostasis and anticholinergic effects, and avoid regular doxylamine use with iloperidone where possible. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Doxylamine with Iloperidone?
MediHelp rates the interaction as moderate. Doxylamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that causes sedation, orthostatic hypotension and QT prolongation. Doxylamine adds sedative and anticholinergic effects, which can increase drowsiness and dizziness.
How serious is the interaction between Doxylamine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, orthostasis and anticholinergic effects, and avoid regular doxylamine use with iloperidone where possible. Review other QT-prolonging drugs.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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