Drug interactions
Doxylamine + Lasmiditan
Severity: Moderate
Doxylamine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and sedation, and doxylamine adds to those effects. The combination may cause marked drowsiness and impaired alertness.
What this interaction means in plain words
Doxylamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depression from lasmiditan's central 5-HT1F effects and doxylamine's H1 blockade.
What to do
Advise patients not to drive for at least 8 hours after lasmiditan and to avoid sedating antihistamines around dosing. Monitor for excessive somnolence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Doxylamine with Lasmiditan?
MediHelp rates the interaction as moderate. Doxylamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and sedation, and doxylamine adds to those effects. The combination may cause marked drowsiness and impaired alertness.
How serious is the interaction between Doxylamine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after lasmiditan and to avoid sedating antihistamines around dosing. Monitor for excessive somnolence.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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