Drug interactions
Doxylamine + Lurasidone
Severity: Moderate
Doxylamine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine. With lurasidone it may cause additive drowsiness and impaired psychomotor function.
What this interaction means in plain words
Doxylamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for oversedation and advise against driving until the response is known. Avoid use in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Lurasidone?
MediHelp rates the interaction as moderate. Doxylamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine. With lurasidone it may cause additive drowsiness and impaired psychomotor function.
How serious is the interaction between Doxylamine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving until the response is known. Avoid use in older adults where possible.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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