Drug interactions
Doxylamine + Nabilone
Severity: Moderate
Doxylamine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine, and with nabilone it can cause excessive drowsiness and impaired alertness. Anticholinergic effects such as confusion and dry mouth may also be worsened.
What this interaction means in plain words
Doxylamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from cannabinoid agonism and H1-antihistamine activity, plus additive anticholinergic effects.
What to do
Avoid using doxylamine as a sleep aid with nabilone where possible, or use the lowest dose and monitor for oversedation. Advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Nabilone?
MediHelp rates the interaction as moderate. Doxylamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine, and with nabilone it can cause excessive drowsiness and impaired alertness. Anticholinergic effects such as confusion and dry mouth may also be worsened.
How serious is the interaction between Doxylamine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using doxylamine as a sleep aid with nabilone where possible, or use the lowest dose and monitor for oversedation. Advise against driving.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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