Drug interactions
Doxylamine + Perphenazine
Severity: Moderate
Doxylamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine, and with perphenazine it can produce marked drowsiness and impaired coordination. Additive anticholinergic effects may cause confusion, urinary retention and constipation, especially in the elderly.
What this interaction means in plain words
Doxylamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Counsel the patient to avoid driving and alcohol, and monitor for excessive sedation and anticholinergic symptoms. Consider an alternative sleep aid in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Perphenazine?
MediHelp rates the interaction as moderate. Doxylamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine, and with perphenazine it can produce marked drowsiness and impaired coordination. Additive anticholinergic effects may cause confusion, urinary retention and constipation, especially in the elderly.
How serious is the interaction between Doxylamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and alcohol, and monitor for excessive sedation and anticholinergic symptoms. Consider an alternative sleep aid in elderly patients.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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