Drug interactions
Doxylamine + Temazepam
Severity: Moderate
Doxylamine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating first-generation antihistamine and temazepam is a benzodiazepine hypnotic. Taken together they produce additive central nervous system depression, with greater drowsiness, impaired psychomotor performance and next-day impairment. Older adults are at particular risk of confusion and falls.
What this interaction means in plain words
Doxylamine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through histamine H1 blockade and enhancement of GABA-A receptor activity.
What to do
Avoid combining two sedative hypnotics for sleep where possible, and warn patients against driving or operating machinery. Use the lowest effective doses and monitor for excessive sedation, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Doxylamine with Temazepam?
MediHelp rates the interaction as moderate. Doxylamine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating first-generation antihistamine and temazepam is a benzodiazepine hypnotic. Taken together they produce additive central nervous system depression, with greater drowsiness, impaired psychomotor performance and next-day impairment. Older adults are at particular risk of confusion and falls.
How serious is the interaction between Doxylamine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sedative hypnotics for sleep where possible, and warn patients against driving or operating machinery. Use the lowest effective doses and monitor for excessive sedation, especially in older patients.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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