Drug interactions
Dronabinol + Flurbiprofen
Severity: Minor
Dronabinol and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized mainly by CYP2C9, and flurbiprofen is a CYP2C9 substrate that competes for this enzyme rather than being a meaningful inhibitor. Any rise in dronabinol exposure is likely small, though additive CNS effects such as drowsiness or dizziness are possible.
What this interaction means in plain words
Dronabinol and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Possible competition for CYP2C9 metabolism, which is theoretical and not well documented.
What to do
No dose change is usually needed; monitor for excess sedation, dizziness or tachycardia when starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronabinol and Flurbiprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Flurbiprofen?
MediHelp rates the interaction as minor. Dronabinol and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronabinol is metabolized mainly by CYP2C9, and flurbiprofen is a CYP2C9 substrate that competes for this enzyme rather than being a meaningful inhibitor. Any rise in dronabinol exposure is likely small, though additive CNS effects such as drowsiness or dizziness are possible.
How serious is the interaction between Dronabinol and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for excess sedation, dizziness or tachycardia when starting the combination.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
