Drug interactions
Dronabinol + Ivosidenib
Severity: Moderate
Dronabinol and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is reported to induce CYP enzymes, so dronabinol exposure may be reduced and its antiemetic or appetite effect may weaken. The effect is predicted rather than well documented.
What this interaction means in plain words
Dronabinol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Enzyme induction by ivosidenib may increase the clearance of dronabinol, which is metabolized by CYP2C9 and CYP3A4.
What to do
Monitor for reduced antiemetic or appetite-stimulating effect and titrate the dronabinol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Dronabinol with Ivosidenib?
MediHelp rates the interaction as moderate. Dronabinol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is reported to induce CYP enzymes, so dronabinol exposure may be reduced and its antiemetic or appetite effect may weaken. The effect is predicted rather than well documented.
How serious is the interaction between Dronabinol and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or appetite-stimulating effect and titrate the dronabinol dose accordingly.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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