Drug interactions
Dronabinol + Lorlatinib
Severity: Minor
Dronabinol and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower dronabinol exposure. Reduced cannabinoid effect, such as weaker antiemetic or appetite-stimulating benefit, may result.
What this interaction means in plain words
Dronabinol and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of dronabinol, a CYP2C9 and CYP3A4 substrate.
What to do
Monitor for reduced dronabinol efficacy and titrate the dose to clinical response if symptom control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Lorlatinib?
MediHelp rates the interaction as minor. Dronabinol and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and may lower dronabinol exposure. Reduced cannabinoid effect, such as weaker antiemetic or appetite-stimulating benefit, may result.
How serious is the interaction between Dronabinol and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dronabinol efficacy and titrate the dose to clinical response if symptom control worsens.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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