Drug interactions
Dronabinol + Nelfinavir
Severity: Moderate
Dronabinol and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can increase dronabinol concentrations, intensifying cannabinoid adverse effects such as sedation, anxiety, confusion and tachycardia.
What this interaction means in plain words
Dronabinol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated dronabinol metabolism by nelfinavir.
What to do
Begin with a lower dronabinol dose and monitor for CNS and cardiovascular effects, adjusting as tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Dronabinol with Nelfinavir?
MediHelp rates the interaction as moderate. Dronabinol and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can increase dronabinol concentrations, intensifying cannabinoid adverse effects such as sedation, anxiety, confusion and tachycardia.
How serious is the interaction between Dronabinol and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with a lower dronabinol dose and monitor for CNS and cardiovascular effects, adjusting as tolerated.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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