Drug interactions
Dronedarone + Entrectinib
Severity: Major
Dronedarone and Entrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and dronedarone also raises entrectinib exposure via CYP3A4 inhibition. This increases the risk of QT-related arrhythmia and entrectinib toxicity.
What this interaction means in plain words
Dronedarone and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Entrectinib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition reducing entrectinib clearance.
What to do
Avoid the combination. If it is unavoidable, reduce the entrectinib dose per labeling and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Dronedarone with Entrectinib?
MediHelp rates the interaction as major. Dronedarone and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and dronedarone also raises entrectinib exposure via CYP3A4 inhibition. This increases the risk of QT-related arrhythmia and entrectinib toxicity.
How serious is the interaction between Dronedarone and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it is unavoidable, reduce the entrectinib dose per labeling and monitor ECG and electrolytes.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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