Drug interactions
Dronedarone + Fesoterodine
Severity: Minor
Dronedarone and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may increase exposure to the active metabolite of fesoterodine. This could increase antimuscarinic adverse effects.
What this interaction means in plain words
Dronedarone and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Fesoterodine belongs to Genitourinary.
Why it happens
Dronedarone inhibits CYP3A4, reducing clearance of the active fesoterodine metabolite.
What to do
No routine dose change; monitor for anticholinergic effects and keep fesoterodine at the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Fesoterodine?
MediHelp rates the interaction as minor. Dronedarone and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone is a moderate CYP3A4 inhibitor and may increase exposure to the active metabolite of fesoterodine. This could increase antimuscarinic adverse effects.
How serious is the interaction between Dronedarone and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for anticholinergic effects and keep fesoterodine at the lowest effective dose.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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