Drug interactions
Dronedarone + Fludrocortisone
Severity: Moderate
Dronedarone and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has little clinically meaningful CYP3A4 induction at usual doses, so a relevant fall in dronedarone exposure is unlikely. A more relevant concern is fludrocortisone-induced hypokalemia, which can increase QT-related arrhythmia risk with dronedarone.
What this interaction means in plain words
Dronedarone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Fludrocortisone causes potassium loss, which may add to dronedarone proarrhythmic risk; CYP3A4 induction is weak and unestablished.
What to do
Monitor serum potassium and magnesium and correct deficits; obtain an ECG if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Dronedarone with Fludrocortisone?
MediHelp rates the interaction as moderate. Dronedarone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has little clinically meaningful CYP3A4 induction at usual doses, so a relevant fall in dronedarone exposure is unlikely. A more relevant concern is fludrocortisone-induced hypokalemia, which can increase QT-related arrhythmia risk with dronedarone.
How serious is the interaction between Dronedarone and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits; obtain an ECG if hypokalemia develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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