Drug interactions
Dronedarone + Galantamine
Severity: Moderate
Dronedarone and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6 and CYP3A4, both of which metabolize galantamine, so galantamine exposure may increase. Both drugs can slow heart rate, raising the possibility of additive bradycardia.
What this interaction means in plain words
Dronedarone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Galantamine belongs to Central Nervous System.
Why it happens
Dronedarone inhibits CYP2D6 and CYP3A4 metabolism of galantamine, with additive bradycardic effects.
What to do
Monitor heart rate and for cholinergic effects such as nausea, vomiting and syncope. Reduce the galantamine dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Dronedarone with Galantamine?
MediHelp rates the interaction as moderate. Dronedarone and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6 and CYP3A4, both of which metabolize galantamine, so galantamine exposure may increase. Both drugs can slow heart rate, raising the possibility of additive bradycardia.
How serious is the interaction between Dronedarone and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for cholinergic effects such as nausea, vomiting and syncope. Reduce the galantamine dose if these occur.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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