Drug interactions
Dronedarone + Ibrutinib
Severity: Major
Dronedarone and Ibrutinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, increases ibrutinib exposure. Higher ibrutinib levels raise the risk of bleeding, arrhythmia including atrial fibrillation, and cytopenias.
What this interaction means in plain words
Dronedarone and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4-mediated metabolism of ibrutinib and may inhibit P-glycoprotein.
What to do
Reduce the ibrutinib dose per labeling for moderate CYP3A4 inhibitors and monitor for bleeding and toxicity. Resume the previous dose after dronedarone is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Dronedarone with Ibrutinib?
MediHelp rates the interaction as major. Dronedarone and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone, a moderate CYP3A4 inhibitor, increases ibrutinib exposure. Higher ibrutinib levels raise the risk of bleeding, arrhythmia including atrial fibrillation, and cytopenias.
How serious is the interaction between Dronedarone and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ibrutinib dose per labeling for moderate CYP3A4 inhibitors and monitor for bleeding and toxicity. Resume the previous dose after dronedarone is stopped.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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