Drug interactions
Dronedarone + Ifosfamide
Severity: Moderate
Dronedarone and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug activated partly by CYP3A4, and dronedarone inhibits this enzyme. Activation may fall, while formation of neurotoxic chloroacetaldehyde could shift, so the effect on efficacy and toxicity is uncertain.
What this interaction means in plain words
Dronedarone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Ifosfamide belongs to Oncology.
Why it happens
Dronedarone inhibition of CYP3A4 alters the bioactivation and metabolism of ifosfamide.
What to do
Monitor for reduced response and for neurotoxicity during ifosfamide treatment. Consider an alternative antiarrhythmic if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Dronedarone with Ifosfamide?
MediHelp rates the interaction as moderate. Dronedarone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a prodrug activated partly by CYP3A4, and dronedarone inhibits this enzyme. Activation may fall, while formation of neurotoxic chloroacetaldehyde could shift, so the effect on efficacy and toxicity is uncertain.
How serious is the interaction between Dronedarone and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for neurotoxicity during ifosfamide treatment. Consider an alternative antiarrhythmic if clinically feasible.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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