Drug interactions
Dronedarone + Irinotecan
Severity: Moderate
Dronedarone and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan and its active metabolite SN-38 depend on CYP3A4 and efflux transporters. Dronedarone may increase exposure, raising the risk of severe diarrhea and neutropenia, although inhibition of CYP3A4 can also reduce conversion to inactive metabolites.
What this interaction means in plain words
Dronedarone and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Irinotecan belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, altering irinotecan disposition.
What to do
Monitor for diarrhea and neutropenia and manage promptly. Reduce the irinotecan dose if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Dronedarone with Irinotecan?
MediHelp rates the interaction as moderate. Dronedarone and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan and its active metabolite SN-38 depend on CYP3A4 and efflux transporters. Dronedarone may increase exposure, raising the risk of severe diarrhea and neutropenia, although inhibition of CYP3A4 can also reduce conversion to inactive metabolites.
How serious is the interaction between Dronedarone and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia and manage promptly. Reduce the irinotecan dose if severe toxicity occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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