Drug interactions
Dronedarone + Istradefylline
Severity: Moderate
Dronedarone and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily inhibits CYP3A4 and may raise dronedarone concentrations. This may increase QT prolongation, bradycardia and other dose-related adverse effects.
What this interaction means in plain words
Dronedarone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4, reducing dronedarone clearance.
What to do
Keep istradefylline at 20 mg daily where possible and monitor heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Dronedarone with Istradefylline?
MediHelp rates the interaction as moderate. Dronedarone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at 40 mg daily inhibits CYP3A4 and may raise dronedarone concentrations. This may increase QT prolongation, bradycardia and other dose-related adverse effects.
How serious is the interaction between Dronedarone and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg daily where possible and monitor heart rate and ECG.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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