Drug interactions
dronedarone + ketoconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ dronedarone exposure/QT; contraindicated.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Avoid; choose non-azole or different antiarrhythmic.
Drug reference
References
Frequently asked questions
Can I take dronedarone with ketoconazole?
The interaction is rated: Contraindicated. ↑ dronedarone exposure/QT; contraindicated.
How serious is the interaction between dronedarone and ketoconazole?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dronedarone and ketoconazole managed?
Avoid; choose non-azole or different antiarrhythmic.
Why do dronedarone and ketoconazole interact?
Strong CYP3A4 inhibition.
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