Drug interactions
Dronedarone + Larotrectinib
Severity: Minor
Dronedarone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and also a weak CYP3A4 inhibitor, so any rise in dronedarone exposure is likely to be small. The clinical significance is not established.
What this interaction means in plain words
Dronedarone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4 and slightly reduce dronedarone metabolism; the effect is not well characterized.
What to do
No routine adjustment is needed. Monitor ECG and QT interval if clinical concern arises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dronedarone with Larotrectinib?
MediHelp rates the interaction as minor. Dronedarone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and also a weak CYP3A4 inhibitor, so any rise in dronedarone exposure is likely to be small. The clinical significance is not established.
How serious is the interaction between Dronedarone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor ECG and QT interval if clinical concern arises.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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