Drug interactions
Dronedarone + Mavacamten
Severity: Major
Dronedarone and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can raise mavacamten concentrations by inhibiting CYP3A4. Excess mavacamten exposure can reduce left ventricular ejection fraction and cause heart failure, and dronedarone is also hazardous in heart failure.
What this interaction means in plain words
Dronedarone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone reduces mavacamten clearance, increasing its negative inotropic effect.
What to do
Avoid the combination where possible, or adjust the mavacamten dose per labeling and perform echocardiographic monitoring of LVEF. Monitor for signs of heart failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Dronedarone with Mavacamten?
MediHelp rates the interaction as major. Dronedarone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone can raise mavacamten concentrations by inhibiting CYP3A4. Excess mavacamten exposure can reduce left ventricular ejection fraction and cause heart failure, and dronedarone is also hazardous in heart failure.
How serious is the interaction between Dronedarone and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or adjust the mavacamten dose per labeling and perform echocardiographic monitoring of LVEF. Monitor for signs of heart failure.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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