Drug interactions
Dronedarone + Metformin-pioglitazone
Severity: Minor
Dronedarone and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and could modestly increase pioglitazone exposure. Because CYP2C8 is the main route of pioglitazone clearance, the effect is expected to be small. Dronedarone also inhibits renal OCT2, which may raise metformin concentrations.
What this interaction means in plain words
Dronedarone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by dronedarone may slightly reduce pioglitazone metabolism, with possible OCT2 inhibition affecting metformin.
What to do
No routine dose change is needed; monitor glucose control and renal function, and watch for fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Dronedarone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone is a moderate CYP3A4 inhibitor and could modestly increase pioglitazone exposure. Because CYP2C8 is the main route of pioglitazone clearance, the effect is expected to be small. Dronedarone also inhibits renal OCT2, which may raise metformin concentrations.
How serious is the interaction between Dronedarone and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glucose control and renal function, and watch for fluid retention.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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