Drug interactions
Dronedarone + Metformin-repaglinide
Severity: Moderate
Dronedarone and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may increase exposure to repaglinide, raising the risk of hypoglycemia. It also inhibits OCT2 and may raise metformin concentrations.
What this interaction means in plain words
Dronedarone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of repaglinide and of renal OCT2 transport of metformin.
What to do
Monitor blood glucose and consider lowering the repaglinide dose. Watch for metformin adverse effects, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Dronedarone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and may increase exposure to repaglinide, raising the risk of hypoglycemia. It also inhibits OCT2 and may raise metformin concentrations.
How serious is the interaction between Dronedarone and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering the repaglinide dose. Watch for metformin adverse effects, especially in renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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