Drug interactions
Dronedarone + Morphine
Severity: Minor
Dronedarone and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, but morphine is mainly cleared by glucuronidation, so a meaningful rise in morphine exposure is unlikely. Any effect is probably small and of limited clinical importance.
What this interaction means in plain words
Dronedarone and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Morphine belongs to Musculoskeletal.
Why it happens
Weak theoretical effect via CYP2D6 inhibition; morphine metabolism is predominantly UGT-mediated, so the effect is not well established.
What to do
No dose change is normally needed; monitor analgesic response and opioid adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Morphine?
MediHelp rates the interaction as minor. Dronedarone and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits CYP2D6, but morphine is mainly cleared by glucuronidation, so a meaningful rise in morphine exposure is unlikely. Any effect is probably small and of limited clinical importance.
How serious is the interaction between Dronedarone and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor analgesic response and opioid adverse effects as usual.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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