Drug interactions
Dronedarone + Nifedipine
Severity: Moderate
Dronedarone and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and increases exposure to calcium channel blockers such as nifedipine, which may cause hypotension and bradycardia. Dronedarone's own exposure may also rise and its effects on conduction are additive.
What this interaction means in plain words
Dronedarone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4, decreasing nifedipine metabolism, with additive hemodynamic and conduction effects.
What to do
Start with a low nifedipine dose and titrate by blood pressure and heart rate. Obtain an ECG after initiation to check for excessive conduction effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Nifedipine?
MediHelp rates the interaction as moderate. Dronedarone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and increases exposure to calcium channel blockers such as nifedipine, which may cause hypotension and bradycardia. Dronedarone's own exposure may also rise and its effects on conduction are additive.
How serious is the interaction between Dronedarone and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low nifedipine dose and titrate by blood pressure and heart rate. Obtain an ECG after initiation to check for excessive conduction effects.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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