Drug interactions
Dronedarone + Oxybutynin
Severity: Minor
Dronedarone and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may raise oxybutynin concentrations, increasing anticholinergic adverse effects.
What this interaction means in plain words
Dronedarone and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Oxybutynin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 by dronedarone reduces oxybutynin first-pass and systemic metabolism.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and confusion, and reduce oxybutynin dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Oxybutynin?
MediHelp rates the interaction as minor. Dronedarone and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone is a moderate CYP3A4 inhibitor and may raise oxybutynin concentrations, increasing anticholinergic adverse effects.
How serious is the interaction between Dronedarone and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and confusion, and reduce oxybutynin dose if they occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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