Drug interactions
Dronedarone + Repaglinide
Severity: Moderate
Dronedarone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is metabolized by CYP2C8 and CYP3A4, and dronedarone inhibits CYP3A4. Increased repaglinide exposure may cause hypoglycemia.
What this interaction means in plain words
Dronedarone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Dronedarone inhibition of CYP3A4 reduces repaglinide clearance.
What to do
Monitor blood glucose and counsel on hypoglycemia symptoms. Reduce the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Dronedarone with Repaglinide?
MediHelp rates the interaction as moderate. Dronedarone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is metabolized by CYP2C8 and CYP3A4, and dronedarone inhibits CYP3A4. Increased repaglinide exposure may cause hypoglycemia.
How serious is the interaction between Dronedarone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel on hypoglycemia symptoms. Reduce the repaglinide dose if glucose falls.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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