Drug interactions
Dronedarone + Rifabutin
Severity: Major
Dronedarone and Rifabutin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can reduce dronedarone concentrations, risking loss of antiarrhythmic effect. Rifabutin is a weaker inducer than rifampin, but a meaningful reduction remains possible.
What this interaction means in plain words
Dronedarone and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction increases the metabolism of dronedarone.
What to do
Avoid concurrent use where possible; dronedarone labeling advises against strong CYP3A4 inducers, so choose alternative therapy or monitor rhythm closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Dronedarone with Rifabutin?
MediHelp rates the interaction as major. Dronedarone and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces CYP3A4 and can reduce dronedarone concentrations, risking loss of antiarrhythmic effect. Rifabutin is a weaker inducer than rifampin, but a meaningful reduction remains possible.
How serious is the interaction between Dronedarone and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; dronedarone labeling advises against strong CYP3A4 inducers, so choose alternative therapy or monitor rhythm closely.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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