Drug interactions
Dronedarone + Selpercatinib
Severity: Major
Dronedarone and Selpercatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib also inhibits P-gp and CYP3A4 to some degree, and risk is higher with electrolyte abnormalities.
What this interaction means in plain words
Dronedarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Selpercatinib belongs to Oncology.
Why it happens
Additive QTc prolongation through effects on cardiac repolarization.
What to do
Avoid if possible; if combined, monitor ECG, potassium, magnesium and calcium and reduce the selpercatinib dose if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Selpercatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Dronedarone 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: substrates of P-glycoproteins, CYP 3A4 or CYP 2D6; "Dronedarone has therefore, the potential to interact on medicinal products substrates of P-glycoproteins, CYP 3A4 or CYP 2D6.") — electronic medicines compendium (UK SmPC)
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Dronedarone with Selpercatinib?
MediHelp rates the interaction as major. Dronedarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib also inhibits P-gp and CYP3A4 to some degree, and risk is higher with electrolyte abnormalities.
How serious is the interaction between Dronedarone and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor ECG, potassium, magnesium and calcium and reduce the selpercatinib dose if QTc becomes prolonged.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
