Drug interactions
Dronedarone + Suvorexant
Severity: Moderate
Dronedarone and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone raises suvorexant exposure through CYP3A4 inhibition. This may cause excess next-day somnolence and impaired driving.
What this interaction means in plain words
Dronedarone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Suvorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of suvorexant.
What to do
Start suvorexant at 5 mg at bedtime and titrate cautiously, up to a maximum of 10 mg. Counsel the patient about daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Dronedarone with Suvorexant?
MediHelp rates the interaction as moderate. Dronedarone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone raises suvorexant exposure through CYP3A4 inhibition. This may cause excess next-day somnolence and impaired driving.
How serious is the interaction between Dronedarone and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at 5 mg at bedtime and titrate cautiously, up to a maximum of 10 mg. Counsel the patient about daytime drowsiness.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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